Detalhe da pesquisa
1.
TDP1 knockout Leishmania donovani accumulate topoisomerase 1-linked DNA damage and are hypersensitive to clinically used antileishmanial drugs.
FASEB J
; 36(4): e22265, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35319800
2.
Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity.
J Med Chem
; 62(7): 3428-3446, 2019 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30897325
3.
Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes.
J Med Chem
; 61(3): 804-817, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29290109